Abstract:

 Objective To compare the difference of the concentration of inflammatory cytokines in the aqueous humor of patients with primary angle-closure glaucoma. Design Experimental study. Participants This study included 16 eyes with acute primary angle-closure glaucoma, 16 eyes with chronic primary angle-closure glaucoma, and 22 eyes with cataract. Methods The concentrations of nine cytokines in aqueous humor were measured with the Luminex suspension array technique. The clinical characteristics of patients were also obtained for correlation analysis. Significant level was P=0.0167. Main Outcome Measures The concentrations of granulocyte colony-stimulating factor (G-CSF), interferon-γ(IFN-γ), interleukin-6，(IL-6), interleukin-8(IL-8), monocyte chemotactic protein-1(MCP-1), platelet derived growth factor-AA(PDGF-AA), PDGF-AB, RANTES and tumor necrosis factor-α (TNF-α) in aqueous humor. Results Compared with those from the senile cataract group, the concentrations of G-CSF, PDGF-AA, IL-6, IL-8, MCP-1, RANTES and TNF-α were significantly higher in the aqueous humor samples from acute primary angle-closure glaucoma (all P<0.0167), and the concentrations of G-CSF, PDGF-AA, IL-6, IL-8, and MCP-1 were significantly elevated in the aqueous humor of patients with chronic primary angle-closure glaucoma (all P<0.0167). There was no significant difference in the concentration of inflammatory factors between acute primary angle-closure glaucoma and chronic primary angle-closure glaucoma (all P>0.0167 ). Conclusions In addition to acute angle closure glaucoma, chronic angle closure glaucoma also had inflammation in ocular anterior segment. (Ophthalmol CHN, 2017, 26: 229-233)

Key words: glaucoma, aqueous humor, inflammatory cytokines